PDRN MICRONEEDLING 

PDRN (Polydeoxyribonucleotide) is a purified mixture of DNA fragments used in regenerative and aesthetic medicine. Its main purpose is to support tissue repair and improve skin quality, rather than simply adding volume or color. 

🔬 How PDRN is thought to work 

PDRN is primarily associated with activation of the adenosine A2A receptor pathway, which can influence: 

• Fibroblast activity → collagen production  

• Angiogenesis → blood-vessel formation and tissue repair  

• Wound-healing processes  

• Reduction of inflammatory signaling  

• Extracellular-matrix remodeling  

In simple terms: PDRN helps create a more favorable environment for skin repair and regeneration. 

PDRN vs PN 

These terms are often confused in aesthetic clinics: 

PDRN 

• Polydeoxyribonucleotide  

• Generally consists of shorter DNA fragments  

• Traditionally associated with tissue repair/wound healing  

• Often discussed in the context of regenerative medicine  

PN (Polynucleotide) 

• Longer DNA polymer chains  

• Often used in aesthetic injectable treatments  

• Intended to improve skin hydration, elasticity and overall quality  

They are related, but PDRN ≠ PN, and products shouldn’t be assumed to be interchangeable simply because both contain DNA-derived polymers. 

PDRN + microneedling 

With microneedling, the skin’s barrier is temporarily disrupted and controlled micro-injuries stimulate wound healing. A PDRN-containing product may then be applied to the skin. 

The proposed combination is: 

Microneedling → controlled injury → collagen remodeling
PDRN → repair/regenerative signaling 

Potential aesthetic targets include: 

• Fine lines  

• Uneven texture  

• Acne scars  

• Post-procedure recovery  

• Dull or photoaged skin  

• Mild loss of elasticity  

However, the evidence for PDRN specifically delivered through microneedling is less established than the evidence for microneedling itself. Much of the clinical literature on PDRN/PN involves other routes of administration 

SCHEDULE AN APPOINTMENT